Mean GC content of shed barcodes does not change substantially during the course of infection.
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posted on 2025-05-23, 17:58 authored by Sylvain Blois, Benjamin M. Goetz, Anik Mojumder, Christopher S. Sullivan<p>A. GC content for the bulk of all barcodes <b>s</b>hed at each time point. B. GC content for the top 10 most shed barcodes for each mouse (“top 10” determined by the greatest amount of a barcode shed at any single time point). Neither panel shows overt trends towards altered nucleotide composition.</p> <p>(PDF)</p>
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- 1. DOI - Is supplement to Shedding dynamics of a DNA virus population during acute and long-term persistent infection
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temporally shifting patternsrelative barcode abundancemonitor parallel infectionslimited productive exchangeconserved across hostsbulk barcode diversitytransmit infectious virusdna virus populationusing murine polyomavirusnumerous different barcodesmany different barcodeslong periods postearly acute phasevirus genomestimes postpolyomavirus ubiquitypersistent phaseindividual barcodesviruses takeunique patterntypically hundredstractable modelterm persistencesubstantially lessstark decreaseshedding dynamicspunctuated sheddingmolecular mechanismsmechanistic basislow levellevel sheddinglevel reactivationlate timesindividual micehigh amountsdriven highconstant lowcases throughout
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