pbio.3001510.s006.docx (847.54 kB)
Maximum likelihood phylogeny used in ancestral reconstruction of Rodent ACE2.
journal contribution
posted on 2021-12-21, 18:34 authored by Gianni M. Castiglione, Lingli Zhou, Zhenhua Xu, Zachary Neiman, Chien-Fu Hung, Elia J. DuhaLRT-SH like branch support values (PhyML) are shown. All data are available in S1 Data. ACE2, angiotensin converting enzyme 2.
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rodent ancestor estimatedmaking humans susceptiblefacilitating cellular infectiondiminishing cellular infectionsubstituting mouse variantssubstituting human variantshuman evolution duemouse 8212ace2 carboxypeptidase activityace2 pmouse ace2human polymorphismseither human 160dog ace2ace2 surfacessubstituted simultaneouslylikely unattainablegenetic contingencygenetic backgroundextreme rarityevolutionary pathwaysdeleterious effectsdeleterious effectcardioprotective functionsbroader range