pbio.3001510.s006.docx (847.54 kB)
Maximum likelihood phylogeny used in ancestral reconstruction of Rodent ACE2.
journal contribution
posted on 2021-12-21, 18:34 authored by Gianni M. Castiglione, Lingli Zhou, Zhenhua Xu, Zachary Neiman, Chien-Fu Hung, Elia J. DuhaLRT-SH like branch support values (PhyML) are shown. All data are available in S1 Data. ACE2, angiotensin converting enzyme 2.
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rodent ancestor estimatedmaking humans susceptiblefacilitating cellular infectiondiminishing cellular infectionsubstituting mouse variantssubstituting human variantshuman evolution duemouse &# 8212ace2 carboxypeptidase activityace2 mouse ace2human polymorphismseither human&# 160dog ace2ace2 surfacessubstituted simultaneouslylikely unattainablegenetic contingencygenetic backgroundextreme rarityevolutionary pathwaysdeleterious effectsdeleterious effectcardioprotective functionsbroader range
