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Intermolecular Three-Component Synthesis of Fluorene Derivatives by a Rhodium-Catalyzed Stitching Reaction/Remote Nucleophilic Substitution Sequence

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journal contribution
posted on 23.06.2020, 17:04 by Masaki Nishida, Donghyeon Lee, Ryo Shintani
A three-component synthesis of multisubstituted fluorene derivatives has been developed by devising a rhodium-catalyzed stitching reaction/remote nucleophilic substitution sequence. A variety of nucleophiles can be installed in the second step including both heteroatom and carbon nucleophiles. An efficient synthesis of 5H-benzo­[a]­fluoren-5-ones has also been realized using N-(2-alkynyl)­benzoylpyrrole as the reaction partner through a new reaction pathway.