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Indole diketopiperazine alkaloids from the deep-sea-derived fungus Aspergillus sp. FS445

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journal contribution
posted on 12.05.2021, 12:00 authored by Zhaoming Liu, Yuchan Chen, Saini Li, Caiyun Hu, Hongxin Liu, Weimin Zhang

Twelve indole diketopiperazine alkaloids (112) including four new ones aspechinulins A‒D (1, 3, 5 and 12) were isolated from the deep-sea-derived fungus Aspergillus sp. FS445. Their structures were elucidated through spectroscopic analysis and the absolute configurations were determined by analyzing the experimental ECD data as well as the quantum chemical calculations. Compounds 1, 3 and 5 represented the first examples of indole diketopiperazine derivatives constructing a C5 unit at 11-NH through an imide linkage. The NO production inhibitory activity of the isolated compounds was evaluated and compounds 25, 7 and 9 exhibited potential inhibitory activities against NO production with the IC50 values in the range of 20 ∼ 90 µM.


This work was supported financially by the National Natural Science Foundation of China (41906106, 31272087), Guangdong Provincial Special Fund for Marine Economic Development Project (GDNRC [2020]042), the Team Project of the Natural Science Foundation of Guangdong Province (2016A030312014), the GDAS’ Project of Science and Technology Development (2019GDASYL-0103007). National Natural Science Foundation of China (NSFC).