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Indium-Catalyzed Denitrogenative Transannulation of Pyridotriazoles: Synthesis of Pyrido[1,2‑a]indoles

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journal contribution
posted on 12.03.2019, 13:11 by Deepa Rawat, Chitrakar Ravi, Abhisek Joshi, Eringathodi Suresh, Kalyanashis Jana, Bishwajit Ganguly, Subbarayappa Adimurthy
Pyrido­[1,2-a]­indoles are known for medicinally and pharmaceutically important compounds; however, the efficient synthetic routes are scarce in the literature. We report herein a convenient and efficient route to synthesize these molecules through indium-catalyzed transannulation of pyridotriazoles with arenes. A library of compounds have been synthesized employing the method developed with various substituted pyrido­[1,2-a]­indole derivatives in moderate to good yields. The density functional theory study using SMDDCB-M06/6-31++G­(d,p)/LANL2DZ//B3LYP/6-31G­(d)/LANL2DZ method suggests that the reactions proceed via indium-carbenoid complex.