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Imputation performance of the Network method upon randomization in the hESC differentiation dataset.

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posted on 2022-02-17, 18:50 authored by Ana Carolina Leote, Xiaohui Wu, Andreas Beyer

Dropout imputation was performed using the network described here (blue), a partially randomized network (light blue) and a fully randomized network (grey).

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    PLOS Computational BiologyPLOS Computational Biology

    Categories

    • Genetics
    • Molecular Biology
    • Immunology
    • Biological Sciences not elsewhere classified
    • Information Systems not elsewhere classified
    • Mathematical Sciences not elsewhere classified
    • Developmental Biology
    • Cancer
    • Infectious Diseases

    Keywords

    available via bioconductorspecific transcriptional regulatorsmean expression acrossgene relationship informationlowly expressed genesgenes equally benefitpackage called adimputemeasurable expression variationdiv >< pcell rna sequencingbest imputation methodexploit external genedifferent imputation methodsdifferent genesspecific featuresexpression levelsexpression levelcell variationbest predictedgiven genebased imputationgenes couldwork representstypically unablethus implementedparadigm shiftincluding cellfindings suggestexclusively usecomputational predictionautomatically determinesart methodsadequately imputed

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