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Highly Active in Situ Catalysts for Anti-Markovnikov Hydration of Terminal Alkynes

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journal contribution
posted on 07.12.2006, 00:00 by Aurélie Labonne, Thomas Kribber, Lukas Hintermann
The anti-Markovnikov hydration of terminal alkynes to give aldehydes is catalyzed by complexes derived in situ from air-stable [CpRu(η6-naphthalene)]PF6 (C) and 6-aryl-2-diphenylphosphinopyridines (L). Ligands L are readily available from a modular synthesis. Increasing the size of the ligand C-6 aryl group in the order R = Ph < mesityl < 2,4,6-triisopropylphenyl < (2,4,6-triphenyl)phenyl gave hydration catalysts of highest known activity.