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High Asymmetric Induction with β-Turn-Derived Palladium Phosphine Complexes

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journal contribution
posted on 2003-07-26, 00:00 authored by Scott J. Greenfield, Anton Agarkov, Scott R. Gilbertson
Work toward the development of a bisphosphine ligand system for the palladium-catalyzed addition to cyclic allyl acetates is reported. A parallel approach using phosphine-containing amino acids in conjunction with natural amino acids was used to develop a selective ligand system. The ligand system was examined while attached to the polymer support as well as in solution. Selectivites with the difficult substrate 3-acetoxycyclopentene of up to 95% ee are reported.

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