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Hemocompatible Interface Control via Thermal-Activated Bio-Inspired Surface PEGylation

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journal contribution
posted on 2015-12-17, 08:07 authored by Mei-Chan Sin, Akon Higuchi, Jie Zheng, Yung Chang, Wen-Lin Lin, Jeff Chen, Arunachalam Chinnathambi, Sulaiman Ali Alharbi

A facile thermal-activated self-copolymerization coating of antifouling layers was designed. PEGylated poly(ethyleneimine) (PEI-PEGMA) was first synthesized, mixed with an alkaline dopamine solution, and then concurrently co-deposited onto versatile substrates of both organic and inorganic materials. Thermal-activated co-deposition of dopamine/PEI-PEGMA could then proceed, giving rise to good hemocompatible performance in respect to low fibrinogen adsorption, ultra-low blood cell adhesion and activation, and almost undetectable hemolytic activities. This work also revealed that the hemocompatible performance was contributed by PEGylated PEI but not dopamine since the poly(dopamine)-coating was shown to induce a high level of fibrinogen adsorption as well as vigorous platelet activation.