gnpl_a_1164701_sm2731.pdf (1.55 MB)
Gracilone, a new sesquiterpene lactone from Tanacetum gracile (Tansies)
journal contribution
posted on 2016-03-28, 05:54 authored by Gulzar Bhat, Akbar Masood, Bashir A. Ganai, Baseerat Hamza, Showkat Ganie, Tasfi Shafi, Ahmed Idris, Abdul S. Shawl, Mudasir A. TantryThe methanolic extract of the Tanacetum gracile afforded the isolation of new sesquiterpene lactone, named gracilone (1) along with four known compounds as 14α-taraxeran-3-one (2), 14α-taraxeran-3-ol (3), apigenin (4) and β-sitosterol (5). The structure of compound 1 was elucidated on the basis of 1D, 2D NMR and MS spectroscopic analysis. Antimicrobial, antioxidant and anticancer activities of all compounds were evaluated, from which gracilone (1) showed a moderate antibacterial activity, while apigenin (4) showed comparatively more antibacterial activity against both grampositive and gramnegative tested strains.