posted on 2020-11-30, 18:59authored byChudong Wu, Jean-François Boisclair Lachance, Michael Z. Ludwig, Ilaria Rebay
(A) A screen shot of the pnt locus from Flybase G-Browse, oriented 5’ to 3’ from right to left, summarizing the annotation of the B, C, D and E isoforms. (B, C) PntP2 (B) and PntP3 (C) are conserved from D. melanogaster (*) to D. virilis (**). Alignments show the unique N-terminal sequences (within the red rectangle) of PntP2 and PntP3. Conserved sequence begins immediately N-terminal to the PLTP (blue line)/SAM region (unboxed). The PntP2 N-terminus is 62% identical and 70.7% similar between D. melanogaster and D. virilis, while the PntP3 N-termini are 57% identical and 63% similar.