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Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi

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posted on 15.02.2013 by Yit-Heng Chooi, Jinxu Fang, Hong Liu, Scott G. Filler, Pin Wang, Yi Tang
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.

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