Gene expression signatures identified in BRC12 and BRC13 tumor cell subpopulations for poor outcome and DNA damage response.

Porter, Warren; Snowden, Eileen; Hahn, Friedrich; Ferguson, Mitchell; Tong, Frances; Dillmore, W. Shannon; Blaesius, Rainer

doi:10.1371/journal.pone.0238594.s009

Gene expression signatures identified in BRC12 and BRC13 tumor cell subpopulations for poor outcome and DNA damage response.

journal contribution

posted on 2020-09-10, 17:29 authored by Warren Porter, Eileen Snowden, Friedrich Hahn, Mitchell Ferguson, Frances Tong, W. Shannon Dillmore, Rainer Blaesius

Overlap of a subpopulation signature associated with poor outcome in lung adenocarcinoma [57] (top) and a signature associated with DNA damage response (DDR) and resistance to PARP inhibition [58] (bottom) are shown in volcano plots.

(PDF)

History

Usage metrics

Keywords

breast cancer PDX model tissue Intr...gene expression profiles gene expression changes High accuracy gene expression IEG depth gene expression analysis PDX models FACS breast cancer patient ITH cell surface markers drug resistance mechanisms

Licence

CC BY 4.0

Gene expression signatures identified in BRC12 and BRC13 tumor cell subpopulations for poor outcome and DNA damage response.

History

Usage metrics

Categories

Keywords

Licence

Exports