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Free-Radical Cyclizations onto Differently Substituted 1,2,3-Triazoles Installed in Sugar Templates

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journal contribution
posted on 28.04.2001, 00:00 by José Marco-Contelles, Mercedes Rodríguez-Fernández
The synthesis and manipulation of differently substituted 1,2,3-triazoles (711 and 1216) installed in sugar templates gave compounds 2934 and 4450, after reaction with tributyltin hydride or tris(trimethylsilyl)silane. Following standard procedures compound 44 was transformed into piperidinose derivative 54. These compounds are chiral, useful building blocks for the synthesis of glycosidase inhibitors of the fused-azole piperidinose type.