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Fit of model to the viral loads of the treated macaques using the saturated source model.

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journal contribution
posted on 09.06.2021, 17:33 by Chad R. Wells, Youfang Cao, David P. Durham, Siddappa N. Byrareddy, Aftab A. Ansari, Nancy H. Ruddle, Jeffrey P. Townsend, Alison P. Galvani, Alan S. Perelson

The measured (≥50 SIV RNA copies/ml solid circles and <50 SIV RNA copies/ml open circles) and model predicted viral loads (solid line) using the best-fit parameter estimates and model variation with the greatest AIC weight for each of the treated macaques and predicted viral dynamics in the absence of the anti-α4β7antibody (dotted black line), panels A)–H). The limit of detection is 50 SIV RNA copies/ml (thin horizontal dashed black line). Treatment with cART occurred between five weeks and 18/19 weeks post-infection (gray area), while eight infusions of the anti-α4β7antibody occurred between nine weeks post-infection and 32 weeks post-infection (purple area). The mechanisms considered include increased viral clearance (red line), viral neutralization (orange line), target cell protection (green line), and increased antigen presentation (without increased viral clearance) (blue line). Parameters for these simulations are in Tables 1 and S14S18 and S2 Text, for the AIC selected mechanism (S5S12 Tables).