First Total Synthesis of Natural
6-Epiplakortolide E

Jung, Mankil; Ham, Jungyeob; Song, Jueun

doi:10.1021/ol026285x.s001

ol026285x_si_001.pdf (2.07 MB)

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First Total Synthesis of Natural 6-Epiplakortolide E

journal contribution

posted on 2002-07-04, 00:00 authored by Mankil Jung, Jungyeob Ham, Jueun Song

Natural 6-epiplakortolide E was first synthesized from readily available 1-bromo-10-phenyldecane in 10 steps by using singlet oxygen-mediated Diels−Alder reaction to form cyclic peroxide followed by a directed iodolactonization to give the peroxylactone core.