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Facile Synthesis of (±)-Paeonilide

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journal contribution
posted on 11.05.2007, 00:00 by Yuguo Du, Jun Liu, Robert J. Linhardt
(±)-Paeonilide, a novel monoterpenoid metabolite from the roots of Paeonia delavayi showing anti-platelet activating factor activity, is convergently synthesized in five steps with 59% overall yield. The application of benzoyl peroxide-promoted radical addition of unsaturated ester to aldehyde and subsequent topologically favored cyclization greatly simplified the synthesis.