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FIRST LINE OF SUBCUTANEOUS ANTI-TNF THERAPY FOR RHEUMATOID ARTHRITIS: A PROSPECTIVE COHORT STUDY

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journal contribution
posted on 15.12.2020, 13:50 by Jéssica Barreto Ribeiro Dos Santos, Michael Ruberson Ribeiro da Silva, Adriana Maria Kakehasi, Franciscode Assis Acurcio, Alessandra Maciel Almeida, Haliton Alves de Oliveira Junior, Pedro Ricardo Kömel Pimenta, Juliana Alvares-Teodoro

Objectives: This study aims to evaluate and compare the use of subcutaneous anti-TNF for RA in a Brazilian real-life setting.

Methods: A prospective cohort of biological disease-modifying antirheumatic drug (bDMARD)-naïve patients treated with adalimumab, etanercept, golimumab, and certolizumab was developed. Medication persistence, disease activity by the Clinical Disease Activity Index (CDAI), functionality by the Health Assessment Questionnaire (HAQ), quality of life by the European Quality of Life 5 Dimensions (EQ-5D), and safety were evaluated at 6 and 12 months.

Results: In a total of 327 individuals, 211 (64.5%) were persistent at 12 months. Patients improved after the use of anti-TNF, with a reduction in the mean of CDAI and HAQ, in addition to an increase in the mean of EQ-5D (p < 0.05). The number of patients who achieved the clinical response was 114 (34.86%) by CDAI, 212 (64.83%) by HAQ, and 215 (65.75%) by EQ-5D at 12 months. There were no statistically significant differences among the drugs (p > 0.05). The anti-TNF was well tolerated.

Conclusion: Anti-TNF reduced disease activity, in addition to improving patients’ functionality and quality of life. Additional pharmacotherapeutic monitoring can be essential to achieve better results.

Funding

This work was supported by the National Council for Scientific and Technological Development - CNPq [grant number: 471819/2013-1] and the Minas Gerais Research Support Foundation - FAPEMIG (grant numbers: [PPM-0015-15 and 03799-16]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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