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Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens

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journal contribution
posted on 20.12.2019, 19:52 by Bei Wang, Yin-Jiao Zhao, Yun-Li Zhao, Ya-Ping Liu, Xiao-Nian Li, Hongbin Zhang, Xiao-Dong Luo
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.