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Enantioselective Synthesis of the ent-Lomaiviticin A Bicyclic Core

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journal contribution
posted on 2012-11-02, 00:00 authored by Ken S. Feldman, Brandon R. Selfridge
The bicyclic core of ent-lomaiviticin A was prepared in 11 operations from (S)-1-phenyl-2-propyn-1-ol in a two-directional route that features (1) a double Ireland Claisen rearrangement and (2) a double olefin metathesis reaction to form the key C–C bonds of the target.