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Download fileEnantioselective Synthesis of (Thiolan-2-yl)diphenylmethanol and Its Application in Asymmetric, Catalytic Sulfur Ylide-Mediated Epoxidation
journal contribution
posted on 07.06.2013, 00:00 authored by Hsin-Yi Wu, Chih-Wei Chang, Rong-Jie CheinThis
work describes an expeditious and efficient preparation of enantiopure
(thiolan-2-yl)diphenylmethanol (2) featuring a double
nucleophilic substitution and Shi epoxidation as key steps. One of
the applications of its benzyl ether derivative to asymmetric sulfur
ylide-mediated epoxidation with up to 92% ee (14 examples) was also
demonstrated herein.