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Enantioselective Metal/Organo-Catalyzed Aerobic Oxidative sp3 C–H Olefination of Tertiary Amines Using Molecular Oxygen as the Sole Oxidant

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journal contribution
posted on 01.08.2012, 00:00 by Gen Zhang, Yunxia Ma, Shoulei Wang, Yaohu Zhang, Rui Wang
An organocatalysis/copper-catalyzed asymmetric oxidative sp3 C–H olefination reaction of tertiary amines with olefins using molecular oxygen as the sole oxidant under mild conditions was realized for the first time. This novel strategy provides an efficient and environmentally friendly way to access diversify optically active C1-alkene tetrahydroisoquinoline derivatives.