ol9003349_si_001.pdf (1.03 MB)
Download file

Enantioselective Conjugate Addition of Nitroalkanes to Vinyl Sulfone: An Organocatalytic Access to Chiral Amines

Download (1.03 MB)
journal contribution
posted on 16.04.2009, 00:00 by Qiang Zhu, Yixin Lu
Organocatalytic asymmetric conjugate addition of nitroalkanes to vinyl sulfone mediated by cinchona alkaloid-derived thiourea catalyst afforded the desired Michael product with good enantioselectivity. The described method, in combination with ready desulfonation, represents a novel approach to access α-alkylated chiral amines.