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Direct Palladium-Catalyzed Carbonylative Transformation of Allylic Alcohols and Related Derivatives

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journal contribution
posted on 2017-09-18, 19:44 authored by Fu-Peng Wu, Jin-Bao Peng, Lu-Yang Fu, Xinxin Qi, Xiao-Feng Wu
A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols for the synthesis of β,γ-unsaturated carboxylic acids has been developed. With formic acid as the CO source, various allylic alcohols were conveniently transformed into the corresponding β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity. The reaction was performed under mild conditions; toxic CO gas manipulation and high-pressure equipment were avoided in this procedure.