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Direct Catalytic Asymmetric Synthesis of β‑Hydroxy Acids from Malonic Acid

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journal contribution
posted on 18.12.2015, 00:00 authored by Hang Gao, Zhenli Luo, Pingjin Ge, Junqian He, Feng Zhou, Peipei Zheng, Jun Jiang
A nickel­(II) catalyzed asymmetric synthesis of β-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.