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CuH-Catalyzed Atropoenantioselective Reduction of Bringmann’s Lactones via Dynamic Kinetic Resolution

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journal contribution
posted on 2019-06-27, 15:43 authored by Le’an Hu, Yao Zhang, Gen-Qiang Chen, Bi-Jin Lin, Qing-Wen Zhang, Qin Yin, Xumu Zhang
A CuH-catalyzed atropoenantioselective reduction of Bringmann’s lactones via dynamic kinetic resolution has been disclosed. This protocol features a broad substrate scope and good functional group tolerance and allows the rapid assembly of various valuable axially chiral biaryls in good to high yields (up to 92% yield) with high to excellent enantioselectivities (up to 96% ee). Moreover, this report represents a rare example that a carbonyl group of esters is reduced under homogeneous asymmetric CuH catalysis.