CuBr-Catalyzed α‑Arylation and Aerobic
Oxidative Dehydrogenative C–N Coupling for the Synthesis of
Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives

Dong, Fang; Liu, Jian-Quan; Wang, Xiang-Shan

doi:10.1021/acs.orglett.0c00497.s001

CuBr-Catalyzed α‑Arylation and Aerobic Oxidative Dehydrogenative C–N Coupling for the Synthesis of Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives

journal contribution

posted on 2020-03-30, 22:29 authored by Fang Dong, Jian-Quan Liu, Xiang-Shan Wang

A copper-catalyzed approach was disclosed for C(sp³)–C(sp²) bond formation via an α-arylation of carbonyl, and the subsequent oxidative dehydrogenation coupling occurred to form a C(sp³)–N bond, wherein O₂ served as a green oxidant. This protocol provided a domino method for the synthesis of spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-ones containing a nitrogen-substituted quaternary carbon center.