CuBr-Catalyzed α‑Arylation and Aerobic
Oxidative Dehydrogenative C–N Coupling for the Synthesis of
Spiro[cyclohexane-1,12′-isoindolo[1,2‑b]quinazolin]-10′-one Derivatives
posted on 2020-03-30, 22:29authored byFang Dong, Jian-Quan Liu, Xiang-Shan Wang
A copper-catalyzed
approach was disclosed for C(sp3)–C(sp2) bond formation via an α-arylation of carbonyl, and
the subsequent oxidative dehydrogenation coupling occurred to form
a C(sp3)–N bond, wherein O2 served as
a green oxidant. This protocol provided a domino method for the synthesis
of spiro[cyclohexane-1,12′-isoindolo[1,2-b]quinazolin]-10′-ones containing a nitrogen-substituted quaternary
carbon center.