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Count of singletons and private doubletons within the included rare deleterious variants.
journal contribution
posted on 2021-09-13, 17:34 authored by Lingyu Zhan, Jiajin Li, Brandon Jew, Jae Hoon SulThe number of total variants represented all rare deleterious variants included under the corresponding MAF threshold.
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three large wholethree identified genesmortem brain samplesidentified significant associationsdisplayed significant influencesalzheimer &# 8217600 brain tissuesidentify functional associationsvariant burden withinwide association studiesonset alzheimer ’integrated bulk rnagene expression alterationdiv >< pvariant genevariant enrichmentfunctional effectvaluable resourcesthoroughly investigatedtaken togethersuccessfully replicatedseq datarelated phenotypesneurofibrillary tanglesmay bringindependent datasetsincorporating scrnagene expressionsfirst applyingeuropean ancestryegenes ),differential expressionscommon typecommon lociclinical researchcell resolution48 post000 individuals
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