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Copper-Catalyzed Synthesis of 2-Unsubstituted, N-Substituted Benzimidazoles

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journal contribution
posted on 18.12.2009, 00:00 authored by Keiichi Hirano, Akkattu T. Biju, Frank Glorius
An efficient copper-catalyzed intramolecular arylation of formamidines forming 2-unsubstituted benzimidazoles in excellent yields is reported. Sixteen examples bearing sterically demanding substituents on nitrogen like Mes, 2,6-diisopropylphenyl, or 2-tert-butylphenyl and tolerating various functional groups demonstrate the utility of this method.