Copper- and Palladium-Catalyzed
Cross-Coupling Reactions
for the Synthesis of N‑Fused Benzo[4,5]imidazo[2,1‑b]thiazole Derivatives via Substituted trans-1,2-Diiodoalkenes, 1H‑Benzo[d]imidazole-2-thiols,
and Halobenzenes

Shen, Guodong; Yang, Bingchuan; Huang, Xianqiang; Hou, Yaxin; Gao, Huan; Cui, Jichun; Cui, Chuansheng; Zhang, Tongxin

doi:10.1021/acs.joc.7b00162.s001

Copper- and Palladium-Catalyzed Cross-Coupling Reactions for the Synthesis of N‑Fused Benzo[4,5]imidazo[2,1‑b]thiazole Derivatives via Substituted trans-1,2-Diiodoalkenes, 1H‑Benzo[d]imidazole-2-thiols, and Halobenzenes

https://doi.org/10.1021/acs.joc.7b00162.s001
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journal contribution

posted on 2017-03-16, 00:00 authored by Guodong Shen, Bingchuan Yang, Xianqiang Huang, Yaxin Hou, Huan Gao, Jichun Cui, Chuansheng Cui, Tongxin Zhang

Two transition metal (Cu and Pd)-catalyzed C–S, C–N, and C–C bond cross-coupling reactions for the preparation of N-fused benzo[4,5]imidazo[2,1-b]thiazole derivatives were developed. A variety of 3-substituted and 2,3-disubstituted benzo[4,5]imidazo[2,1-b]thiazoles were efficiently and conveniently synthesized from the coupling reaction via trans-1,2-diiodoalkenes, 1H-benzo[d]imidazole-2-thiols, and halobenzenes in moderate to excellent yields.