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Copper-Catalyzed Diamination of Alkenes using o‑Benzoylhydroxylamines to Access the Four Azaindoline Families

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posted on 2024-10-04, 11:34 authored by Jinwoo Lee, Chaeeun Lee, Kyung Ah Kim, Suhui Kim, Nayoung Lim, Ki Bum Hong, Sungwook Choi
A mild and efficient method for the copper-catalyzed diamination of alkenes is described. In this reaction, o-benzoylhydroxylamine serves as an electrophilic nitrogen source for the regioselective formation of C–N bonds. This transformation provides a novel strategy for synthesizing all four isomeric 2,3-disubstituted azaindoline families and offers a wide substrate scope.

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