Comparison of previously-identified within-serotype differences in strain invasiveness with the results of this analysis.
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posted on 2022-02-17, 18:49 authored by Alessandra Løchen, James E. Truscott, Nicholas J. CroucherThe exclusion of strain and serotype combinations represented by fewer than ten isolates, summed across carriage and disease, meant that some within-serotype differences between strains were not tested in this analysis.
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public health interventionsproblematic following vaccineheterogeneous geographical distributionhence genomic surveillancefound significant evidenceaccurately reproduced observationsrstan package (<disease burden attributablecause symptomatic diseasebayesian models producedsmaller sample sizesidentified historically rareenabling ongoing metadiv >< pstreptococcus pneumoniae opportunistic pathogens dependssample sizespneumoniae package allowsopportunistic pathogensmodels convergedinvasive diseasedisease casestyped microbestherefore likelystable fitsserotype variationserotype informationodds ratiosmodel comparisonsinfections causedidentify newhypothesis testinghealthy carriersdimensionless valuesbayes factorsbacterial populationasymptomatic colonisationassociated disruption
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