Comparison of model fits to strain and serotype data from child carriage and disease with modified carriage sample sizes using Bayes factors calculated with bridge sampling.
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posted on 2022-02-17, 18:48 authored by Alessandra Løchen, James E. Truscott, Nicholas J. CroucherIn this analysis, the carriage sample size for three studies (Finland pre-PCV, Oxford pre-PCV and Stockholm pre-PCV) was increased 100-fold, to test the sensitivity of the model comparisons to the uncertainty in this parameter (Text S2). The table is displayed as described for Table S5.
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public health interventionsproblematic following vaccineheterogeneous geographical distributionhence genomic surveillancefound significant evidenceaccurately reproduced observationsrstan package (<disease burden attributablecause symptomatic diseasebayesian models producedsmaller sample sizesidentified historically rareenabling ongoing metadiv >< pstreptococcus pneumoniae opportunistic pathogens dependssample sizespneumoniae package allowsopportunistic pathogensmodels convergedinvasive diseasedisease casestyped microbestherefore likelystable fitsserotype variationserotype informationodds ratiosmodel comparisonsinfections causedidentify newhypothesis testinghealthy carriersdimensionless valuesbayes factorsbacterial populationasymptomatic colonisationassociated disruption
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