ol050245m_si_002.pdf (12.95 MB)
Chemoselective Syntheses of γ-Butyrolactams Using Vinyl Sulfilimines and Dichloroketene
journal contributionposted on 2005-05-12, 00:00 authored by Joseph P. Marino, Nanfei Zou
Reactions between vinyl sulfilimines and dichloroketene generated in situ from trichloroacetyl chloride in the presence of zinc−copper couple give mixtures of α-dichloro-γ-butyrolactams and α-dichloro-γ-butyrolactone imines. Fine-tuning of substituents within vinyl sulfilimines results in reactions with good chemoselectivity and yield for lactams.