Chemical Constituents of a Marine Fungus, Arthrinium sacchari
journal contributionposted on 2011-07-22, 00:00 authored by Mariko Tsukada, Miyuki Fukai, Kazuhiko Miki, Takeshi Shiraishi, Toshihiro Suzuki, Kazuto Nishio, Takashi Sugita, Masahiro Ishino, Kaoru Kinoshita, Kunio Takahashi, Motoo Shiro, Kiyotaka Koyama
Three new diterpenes, myrocin D (1), libertellenone E (2), and libertellenone F (3), and a new isocoumarin, decarboxyhydroxycitrinone (4), were isolated from the marine fungus Arthrinium sacchari, together with three known compounds (5–7). The structures of 1–4 were elucidated from spectroscopic data (NMR, MS, IR), and the absolute configurations of 1–3 were determined by X-ray diffraction analysis. The antiangiogenic activity of these compounds was evaluated by measuring their antiproliferation effects on human umbilical vein endothelial cells (HUVECs) and human umbilical artery endothelial cells (HUAECs). Compounds 4–7 showed inhibitory activity.
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marine fungus Arthrinium sacchariumbilical veinHUVECspectroscopic datamyrocinHUAECumbilical arteryantiangiogenic activityArthrinium sacchariThreechemical ConstituentslibertellenoneIRcompoundantiproliferation effectsconfigurationditerpeneNMRdiffractionanalysisMarine FungusMSisocoumarindecarboxyhydroxycitrinoneCompound