Pd-catalyzed amination reaction of aryl halides has
attracted much attention in recent years. This review underscores selected
important recent developments in the catalysis of one of the kind amination
reaction so-called Buchwald-Hartwig amination reaction. This development has
been achieved via utilization of sterically hindered phosphine ancillary
ligands. Our purpose here is giving information to the readers about recent
advances in this strategy for the C-N bond formation, especially applied for
construction of various heterocyclic systems. In this review, we also
deliberate the applications of this name reaction as an important C-N
cross-coupling reaction applied to the total synthesis of natural products.