Boron Lewis Acid Catalyzed Intermolecular trans-Hydroarylation of Ynamides with Hydroxyarenes

An atom-economic protocol for the efficient and highly chemo- and stereoselective trans-hydroarylation of ynamides with hydroxyarenes catalyzed by B­(C₆F₅)₃ has been developed. Use of readily available starting materials, low catalyst loading, mild reaction conditions, a broad substrate scope, ease of scale-up, and versatile functionalizations of the enamide products make this approach very practical and attractive.