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Benzannulated 6,5-Spiroketals from Donor–Acceptor Cyclopropanes

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journal contribution
posted on 2019-03-29, 14:11 authored by Sinan Gai, Nigel T. Lucas, Bill C. Hawkins
A rapid and facile synthesis of benzannulated 6,5-spiroketals from vinyl 1,1-diacylcyclopropanes is reported. The method utilizes mild reaction conditions with good to excellent yields and high diastereoselectivity. This methodology was then used to construct the core of berkelic acid.