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Assembling Polycyclic Bisguanidine Motifs Resembling Batzelladine Alkaloids by Double Tethered Biginelli Condensations

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journal contribution
posted on 2003-11-13, 00:00 authored by Frederick Cohen, Shawn K. Collins, Larry E. Overman
Double tethered Biginelli condensations furnish linked polycyclic bisguanidines or bisureas. Alteration of the bis-β-ketoester component allows bispolycyclic guanidine motifs to be constructed that resemble natural batzelladine alkaloids or have novel linkages.