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Arthpyrones A–C, Pyridone Alkaloids from a Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3

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journal contribution
posted on 2015-02-06, 00:00 authored by Junfeng Wang, Xiaoyi Wei, Xiaochu Qin, Xiuping Lin, Xuefeng Zhou, Shengrong Liao, Bin Yang, Juan Liu, Zhengchao Tu, Yonghong Liu
Three new 4-hydroxy-2-pyridone alkaloids, arthpyrones A–C (13), were isolated from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Their structures were elucidated on the basis of spectroscopic analysis, CD spectra, quantum chemical calculation, and X-ray single-crystal diffraction analysis. Compounds 1 and 2 possessed a 2-pyridone core featured with a decalin moiety linked via a carboxide bridge bearing a novel oxabicyclo[3.3.1]­nonane ring system rarely discovered in nature. A possible biosynthetic pathway for them was proposed.