Antibacterial Neurymenolides from the Fijian Red Alga Neurymenia fraxinifolia
journal contributionposted on 2009-01-01, 00:00 authored by E. Paige Stout, Adam P. Hasemeyer, Amy L. Lane, Theresa M. Davenport, Sebastian Engel, Mark E. Hay, Craig R. Fairchild, Jacques Prudhomme, Karine Le Roch, William Aalbersberg, Julia Kubanek
Two novel α-pyrone macrolides, neurymenolides A (1) and B (2), were isolated from the Fijian red alga Neurymenia fraxinifolia and characterized using a combination of NMR and mass spectral analyses. These molecules represent only the second example of α-pyrone macrolides, with 1 existing as interchanging atropisomers due to restricted rotation about the α-pyrone ring system. Neurymenolide A (1) displayed moderately potent activities against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF).