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An Enantioselective Synthetic Route to cis-2,4-Disubstituted and 2,4-Bridged Piperidines

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journal contribution
posted on 05.09.2008, 00:00 by Mercedes Amat, Maria Pérez, Annamaria T. Minaglia, Joan Bosch
A synthetic route to enantiopure cis-2,4-disubstituted and 2,4-bridged piperidines is reported, the key step being a stereoselective conjugate addition of an organocuprate to a phenylglycinol-derived unsaturated lactam bearing a substituent at the 8a-position.