40478_2022_1437_MOESM1_ESM.pdf (640.09 kB)
Additional file 1 of TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome
journal contribution
posted on 2022-09-20, 08:49 authored by Luis Gustavo Perez-Rivas, Julia Simon, Adriana Albani, Sicheng Tang, Sigrun Roeber, Guillaume Assié, Timo Deutschbein, Martin Fassnacht, Monica R. Gadelha, Ad R. Hermus, Günter K. Stalla, Maria A. Tichomirowa, Roman Rotermund, Jörg Flitsch, Michael Buchfelder, Isabella Nasi-Kordhishti, Jürgen Honegger, Jun Thorsteinsdottir, Wolfgang Saeger, Jochen Herms, Martin Reincke, Marily TheodoropoulouAdditional file 1. Supplementary Table 1: Description of study cohort. Supplementary Table 2: Primers used for TP53 amplification and Sanger sequencing. Supplementary Table 3: Common TP53 variants in the study cohort. Supplementary Table 4: Comparison of TP53 mutant versus TP53 wild type group. Supplementary Figure 1. Chromatograms showing the TP53 variants found in the corticotroph tumor of patient #1 and #8 (Table 1). A. The variant c.398T>A was present in homozygocity in the tumor and absent in the blood. B. The variant c.1009C>G is detected in all available surgical specimens in this patient. First and 2nd surgeries were Cushing’s disease tumors and 4th and 5th CTP-BADX/NS.
