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Additional file 1 of TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome

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posted on 2022-09-20, 08:49 authored by Luis Gustavo Perez-Rivas, Julia Simon, Adriana Albani, Sicheng Tang, Sigrun Roeber, Guillaume Assié, Timo Deutschbein, Martin Fassnacht, Monica R. Gadelha, Ad R. Hermus, Günter K. Stalla, Maria A. Tichomirowa, Roman Rotermund, Jörg Flitsch, Michael Buchfelder, Isabella Nasi-Kordhishti, Jürgen Honegger, Jun Thorsteinsdottir, Wolfgang Saeger, Jochen Herms, Martin Reincke, Marily Theodoropoulou
Additional file 1. Supplementary Table 1: Description of study cohort. Supplementary Table 2: Primers used for TP53 amplification and Sanger sequencing. Supplementary Table 3: Common TP53 variants in the study cohort. Supplementary Table 4: Comparison of TP53 mutant versus TP53 wild type group. Supplementary Figure 1. Chromatograms showing the TP53 variants found in the corticotroph tumor of patient #1 and #8 (Table 1). A. The variant c.398T>A was present in homozygocity in the tumor and absent in the blood. B. The variant c.1009C>G is detected in all available surgical specimens in this patient. First and 2nd surgeries were Cushing’s disease tumors and 4th and 5th CTP-BADX/NS.


Deutsche Forschungsgemeinschaft Medizinischen Fakultät, Ludwig-Maximilians-Universität München Else Kröner-Fresenius-Stiftung Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro Universitätsklinik München (6933)