13578_2021_699_MOESM1_ESM.docx (1.58 MB)

Additional file 1 of PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma

Download (1.58 MB)
journal contribution
posted on 2021-10-30, 03:26 authored by Chunying Liu, Xuejing Lin, Bin Sun, Ziming Mao, Lei Chen, Haihua Qian, Changqing Su
Additional file 1: Figure S1. High expression of PRCC is associated with poor prognosis of HCC patients in TCGA database ( ). a. The high expression of PRCC is significantly negatively correlated with the overall survival of HCC patients (P < 0.05). b. The high expression of PRCC is not significantly correlated with the progression-free survival of HCC patients (P = 0.183). Figure S2. The effects of PRCC on the biological behavior of HCC cells. a. PRCC has no significant effect on the proliferation of HCC cells. b. PRCC inhibits the colony forming ability of HCC cells (*, P<0.05). c, d. PRCC inhibits the migration and invasion of HCC cells in vitro. The histograms are the quantitative analysis results (*, P < 0.05; **, P < 0.01; ***, P < 0.001). All data were representative of three independent experiments. Table S1. Primer sequences of RT-qPCR. Table S2. Antibody information.


National Natural Science Foundation of China National Key R&D Program of China