Additional file 1 of BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

Quezada, Esteban; Cappelli, Claudio; Diaz, Iván; Jury, Nur; Wightman, Nicholas; Brown, Robert H.; Montecino, Martín; van Zundert, Brigitte

doi:10.6084/m9.figshare.14227789.v1

13148_2021_1039_MOESM1_ESM.pdf (850.92 kB)

Additional file 1 of BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

journal contribution

posted on 2021-03-17, 04:52 authored by Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown, Martín Montecino, Brigitte van Zundert

Additional file 1: Fig. S1. Bromodomain inhibitors enhance C9ORFF72 gene promoter-driven expression in SH-SY5Y LE200 G4C2 reporter cell lines. Table S1. Epidrugs used in screening. Table S2. TaqMan probes information.