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Additional file 1 of BET bromodomain inhibitors PFI-1 and JQ1 are identified in an epigenetic compound screen to enhance C9ORF72 gene expression and shown to ameliorate C9ORF72-associated pathological and behavioral abnormalities in a C9ALS/FTD model

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posted on 2021-03-17, 04:52 authored by Esteban Quezada, Claudio Cappelli, Iván Diaz, Nur Jury, Nicholas Wightman, Robert H. Brown, Martín Montecino, Brigitte van Zundert
Additional file 1: Fig. S1. Bromodomain inhibitors enhance C9ORFF72 gene promoter-driven expression in SH-SY5Y LE200 G4C2 reporter cell lines. Table S1. Epidrugs used in screening. Table S2. TaqMan probes information.

Funding

ALS Therapy Alliance Amyotrophic Lateral Sclerosis Association FightMND CONICYT PIA/BASAL DRI-USA FONDECYT FONDAP FONDECYT CONICYT ALS-One ALS-FindingACure the Angel Fund for ALS Research the Cellucci Fund for ALS Research the Michael Rosenfeld Fund National Institutes of Health

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