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Additional file 13: of Germline and somatic variations influence the somatic mutational signatures of esophageal squamous cell carcinomas in a Chinese population

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journal contribution
posted on 16.07.2018, 05:00 by Jintao Guo, Jiankun Huang, Ying Zhou, Yulin Zhou, Liying Yu, Huili Li, Lingyun Hou, Liuwei Zhu, Dandan Ge, Yuanyuan Zeng, Bayasi Guleng, Qiyuan Li
Figure S8. The effects of TP53, ZNF750, CDC27 and other clinical features on the activity of the “NpCpG” signature and the “AID/APOBEC-2” signature in the subtypes of ESCC. The somatic status and the genetic burden of TP53 influence the activities of the “NpCpG” signature (a) and the “AID/APOBEC-2” signature (b) in subtype 1 to 3, independent of other clinical features. And the somatic status and the genetic burden of ZNF750 influence the activities of the “NpCpG” signature (c) and the “AID/APOBEC-2” signature (d) in subtype 1 to 3, independent of other clinical features. The somatic copy number amplification and the genetic burden of CDC27 influence the activity of the “NpCpG” signature (e) and the “AID/APOBEC-2” signature (f) in subtype 1 to 3, independent of other clinical features. P values are based on multivariate linear regression analysis: *P < 0.05, **P < 0.01, ***P < 0.001. (PDF 892 kb)

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National Natural Science Foundation of China

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