Activity against adult S. mansoni in mice (low infection rates).
Mice infected with S. mansoni for 9 weeks (worms are in the adult stage) were treated with methylene blue (MB) or pyronaridine (PY). Negative control treatment: No drug and solvent, positive control treatment: Praziquantel (PZQ). WBR is referred to the “No drug” group. WBR: Worm burden reduction, LGS: Liver granulation score. * 1 mouse died during the treatment week. a Interquartile range: IQR. Results from one experiment are shown. Of note: These are results of the repeated experiment, but as infection rates in control mice were low, they are presented here separately.