Activity against adult <i>S</i>. <i>mansoni</i> in mice (low infection rates).
journal contribution
posted on 2021-06-24, 17:42 authored by Erik Koehne, Nina Zander, Miriam Rodi, Jana Held, Wolfgang Hoffmann, Rella Zoleko-Manego, Michael Ramharter, Ghyslain Mombo-Ngoma, Peter G. Kremsner, Andrea Kreidenweiss<p>Mice infected with <i>S</i>. <i>mansoni</i> for 9 weeks (worms are in the adult stage) were treated with methylene blue (MB) or pyronaridine (PY). Negative control treatment: No drug and solvent, positive control treatment: Praziquantel (PZQ). WBR is referred to the “No drug” group. WBR: Worm burden reduction, LGS: Liver granulation score. * 1 mouse died during the treatment week. <sup>a</sup> Interquartile range: IQR. Results from one experiment are shown. Of note: These are results of the repeated experiment, but as infection rates in control mice were low, they are presented here separately.</p> <p>(PDF)</p>
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Pyronaridine treatmentTrial registration ClinicalTrials.g...10 μ Mworm burdenmalaria parasitesprepatent stagespatient managementalternative treatment strategies1 controlSchistosoma Background Schistosomiasis30 μ Madult schistosomeshaematobium egg excretionantischistosomal compoundsantimalarial pyronaridineSchistosoma infectionsstage schistosomulaResults Amongst 16 drugsantiplasmodial compoundsmethyleneprepatent stagepilot trialantimalarial drugvivo activityschistosomiasis treatmentdrug resistance12 animalsConclusion Pyronaridineantimalarial drug combination pyron...4 childrenvivo adult wormsmice adult stagesschistosome infectionsadult worms
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