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Acremolin D, a new acremolin alkaloid from the deep-sea sediment derived Aspergillus sydowii fungus

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journal contribution
posted on 12.05.2021, 12:00 by Siwen Niu, Ziming Chen, Shengxiang Pei, Zongze Shao, Gaiyun Zhang, Bihong Hong

Chemical investigation of the deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of one new acremolin type alkaloid (acremolin D, 1) and five known alkaloids (2‒6). The planar structure of 1 was established by the extensive analyses of the NMR and HRESIMS data, while its absolute configuration was assigned by the comparison of the experimental and calculated ECD data. Acremolin D (1) represented the second analogue of acremolin found in nature. All compounds were evaluated for their cytotoxic activities against six human cancer cell lines (A549, Hela-S3, MCF-7, HepG2, K562, and SF-268). As a result, compounds 1 and 2 exhibited a certain inhibitory effects against the proliferation of the A549, Hela-S3, HepG2, and K562 cell lines at the concentration of 20 µM.

Funding

This study was financially funded by the Scientific Research Foundation of Third Institute of Oceanography (2018018) and Science and Technology Planning Project of Guangdong Province (2018A0303070005).

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