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A new diarylhexane and two new diarylpropanols from the roots of Knema globularia

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posted on 16.09.2020 by Uraiwan Sriphana, Chavi Yenjai, Jittra Suthiwong, Kitisak Poopasit

A new diarylhexane, kneglobularone B (1) and two new diarylpropanols, kneglobularols A − B (2 − 3) along with seven known compounds (4 − 10) were isolated and characterized from the roots of Knema globularia. It is the first time to find arylpropyl quinone (4) and isoflavone (8) in Myristicaceae family. In addition, 5 was found for the first time in Knema genus. Their structures were elucidated by UV, IR, MS, 1 D and 2 D NMR techniques. Compound 4 exhibited strong cytotoxicity against the NCI − H187 and MCF − 7 cell lines with IC50 values of 3.08 and 6.68 µg/mL, respectively.

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